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Novel variants in LAMA3 and COL7A1 and recurrent variant in KRT5 underlying epidermolysis bullosa in

Frontiers of Medicine 2022, Volume 16, Issue 5, Pages 808-814 doi: 10.1007/s11684-021-0878-x

Abstract: Chinese families with EB, and eight variants including a novel nonsense variant (c.47G>A, p.W16*) in LAMA3i>, a known recurrent variant (c.74C>T, p.P25L) in KRT5i>, 2 novel (c.2531T>A, p.V844E; cCOL7A1 i>were detected.Notably, this study identified a nonsense variant in LAMA3i> that causes EB within the Chinese populationand revealed that this variant resulted in a reduction in LAMA3i> mRNA and protein expression levels

Keywords： epidermolysis bullosa LAMA3i> COL7A1i> KRT5i> Chinese families

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Identification of variants associated with sporadic thoracic aortic dissection: a case--control study

Frontiers of Medicine 2021, Volume 15, Issue 3, Pages 438-447 doi: 10.1007/s11684-020-0826-1

Abstract: We found that COL3A1i> was significantly relevant to STAD (Pi> = 7.35 × 10⁻⁶) after10 000 times permutation test (Pi> = 2.49 × 10⁻³)., replicated our results (Pi> = 0.021).Further bioinformatics analysis showed that COL3A1i> was highly expressed in dissected aortic tissuesCOL3A1i> could increase the risk of STAD through the ECM pathway.

Keywords： sporadic thoracic aortic dissection exome sequencing gene COL3A1i> case–control study extracellular

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NES1i>/KLK10i> and hNISi> gene therapy enhanced iodine-131 internal radiation in PC3 proliferation

Jiajia Hu, Wenbin Shen, Qian Qu, Xiaochun Fei, Ying Miao, Xinyun Huang, Jiajun Liu, Yingli Wu, Biao Li

Frontiers of Medicine 2019, Volume 13, Issue 6, Pages 646-657 doi: 10.1007/s11684-018-0643-y

Abstract: gene is thought to be a tumor-suppressor gene.Our previous study found that overexpression of gene in PC3 cell line could slow down the tumor proliferationI radiation therapy uptake by overexpressed hNIS protein.therapy and I radiation therapy mediated by overexpressed hNIS protein had the best tumor proliferativeuptake in overexpressed PC3 cells.

Keywords： androgen-independent prostate cancer normal epithelial cell-specific 1/kallikrein 10 sodium/iodide symporter

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APPLE SUMO E3 LIGASE MDSIZ1 NEGATIVELY REGULATES DROUGHT TOLERANCE

Baohua CHU, Jia SUN, Huan DANG, Ziqing MA, Shuang ZHAO, Qingmei GUAN, Xuewei LI

Frontiers of Agricultural Science and Engineering Pages 247-261 doi: 10.15302/J-FASE-2021388

Abstract: MdSIZ1 is a SUMO (small ubiquitin-like modifier) E3 ligase that promotes SUMO binding to substrate proteinsTaken together, these results indicate that apple MdSIZ1 negatively regulates drought stress by enhancing

Keywords： apple drought tolerance gene expression MdSIZ1i>

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RR1i> and RR2i> gene deletion affects the immunogenicity of a live attenuated pseudorabies

Shijun YAN,He YAN,Chaolin ZHANG,Tongyan WANG,Qingyuan YANG,Zhe SUN,Yan XIAO,Feifei TAN,Xiangdong LI,Kegong TIAN

Frontiers of Agricultural Science and Engineering 2016, Volume 3, Issue 1, Pages 81-86 doi: 10.15302/J-FASE-2016088

Abstract: In this study, we deleted and genes based on a / / triple gene-deleted pseudorabies virus and tested

Keywords： pseudorabies virus RR1i> and RR2i> ribonucleotide reductase vaccine candidate

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Distinct gene expression pattern of mutations coordinated by target repression and promoter hypermethylation

Frontiers of Medicine 2022, Volume 16, Issue 4, Pages 627-636 doi: 10.1007/s11684-020-0815-4

Abstract: However, RUNX1i> mutations have been largely under-explored compared with RUNX1i> fusions mainlyThen, based on RNA-seq data from The Cancer Genome Atlas AML cohort, we developed a 300-gene signaturein patients with RUNX1i> mutations.regulated genes also contributed to dysregulation in RUNX1i>-mutated AML.This study revealed the distinct gene expression pattern of RUNX1i> mutations and the underlying

Keywords： RUNX1i> gene mutation acute myeloid leukemia transcriptional repression DNA methylation

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Identification of an E3 ligase-encoding gene

Yanfei Zhang, Xinchun Zhao, Yongchun Zhou, Min Wang, Guangbiao Zhou

Frontiers of Medicine 2020, Volume 14, Issue 3, Pages 318-326 doi: 10.1007/s11684-019-0708-6

Abstract: We found that silencing of one of the candidates, that encodes an E3 ubiquitin ligase essential forWe further evaluated the significance of in NSCLCs and found that this gene was more elevated in tumor

Keywords： RFWD3i> NSCLC prognosis tobacco smoke

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Construction of a CaHPO4-PGUS1 hybrid nanoflower through protein-inorganic self-assembly, and its applicationin glycyrrhetinic acid 3-O-mono-β-D-glucuronide preparation

Tian Jiang, Yuhui Hou, Tengjiang Zhang, Xudong Feng, Chun Li

Frontiers of Chemical Science and Engineering 2019, Volume 13, Issue 3, Pages 554-562 doi: 10.1007/s11705-019-1834-z

Abstract: Glycyrrhetinic acid 3- -mono- -D-glucuronide (GAMG), an important pharmaceutical intermediate and functionalUsing site-directed mutagenesis, we previously obtained a variant of -glucuronidase from Li-3 (PGUS1In this study, a facile method was established to prepare a CaHPO -PGUS1 hybrid nanoflower for enzymeUnder optimal conditions, 1.2 mg of a CaHPO -PGUS1 hybrid nanoflower precipitate with 71.2% immobilizationand scanning electron microscope results showed that the enzyme was encapsulated in the CaHPO -PGUS1

Keywords： βi>-glucuronidase enzyme-inorganic hybrid nanoflower biotransformation glycyrrhizin glycyrrtinicacid 3-Oi>-mono-βi>-D-glucuronide

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Band-gap tunable (Ga_xi>In₁₋_xi>)₂O₃ layer Research Articles

Fabi Zhang, Jinyu Sun, Haiou Li, Juan Zhou, Rong Wang, Tangyou Sun, Tao Fu, Gongli Xiao, Qi Li, Xingpeng Liu, Xiuyun Zhang, Daoyou Guo, Xianghu Wang, Zujun Qin,zhangfabi@outlook.com,qinzj@guet.edu.cn

Frontiers of Information Technology & Electronic Engineering 2021, Volume 22, Issue 10, Pages 1370-1378 doi: 10.1631/FITEE.2000330

Abstract: Multicomponent oxide (GaIn)O films are prepared on (0001) sapphire substrates to realize a tunable band-gap by technology followed by thermal annealing. The optical properties and band structure evolution over the whole range of compositions in ternary compounds (GaIn)O are investigated in detail. The X-ray diffraction spectra clearly indicate that (GaIn)O films with Ga content varying from 0.11 to 0.55 have both cubic and monoclinic structures, and that for films with Ga content higher than 0.74, only the monoclinic structure appears. The transmittance of all films is greater than 86% in the visible range with sharp absorption edges and clear fringes. In addition, a blue shift of ultraviolet absorption edges from 380 to 250 nm is noted with increasing Ga content, indicating increasing band-gap energy from 3.61 to 4.64 eV. The experimental results lay a foundation for the application of transparent conductive compound (GaIn)O thin films in photoelectric and photovoltaic industry, especially in display, light-emitting diode, and solar cell applications.

Keywords： (GaxIn1−x)2O3薄膜；带隙可调谐；磁控溅射

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Association of gene variants with juvenile amyotrophic lateral sclerosis

Frontiers of Medicine doi: 10.1007/s11684-023-1005-y

Abstract: A variation within TRMT2Bi> (c.1356G>T; p.K452N) was identified to be associated with ALS in a familyA decreased number of mitochondria, swollen mitochondria, lower expression of ND1, decreased mitochondrialfunctionally in patient-originated lymphoblastoid cell lines and TRMT2Bi> interfering HEK293 cellsFurther, TRMT2Bi> variations overexpression cells also displayed decreased ND1.In conclusion, a novel JALS-associated gene called TRMT2Bi> was identified, thus broadening the

Keywords： TRMT2Bi> amyotrophic lateral sclerosis mitochondrial complex I tRNA methylation reactive oxygen

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Gene delivery into isolated

Nan Zheng, Ziyuan Song, Yang Liu, Lichen Yin, Jianjun Cheng

Frontiers of Chemical Science and Engineering 2017, Volume 11, Issue 4, Pages 521-528 doi: 10.1007/s11705-017-1612-8

Abstract: The application of gene delivery materials has been mainly focused on mammalian cells while rarely extendedThis study therefore widens the utilities of helical polypeptide as a unique category of gene deliverymaterials, and may find their promising applications toward plant gene delivery.

Keywords： αi>-helical polypeptide plant gene delivery protoplast intact leaves transfection

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A novel aldo-keto reductase gene,

Jinxi HUO, Bing DU, Sifan SUN, Shaozhen HE, Ning ZHAO, Qingchang LIU, Hong ZHAI

Frontiers of Agricultural Science and Engineering 2018, Volume 5, Issue 2, Pages 206-213 doi: 10.15302/J-FASE-2018225

Abstract: In this study, the gene was isolated from sweet potato.The relative expression levels of increased significantly (approximately 3-fold) after exposure to

Keywords： cadmium stress IbAKRi> Ipomoea batatasi> sweet potato

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Electroactivity of the magnetotactic bacteria AMB-1 and MSR-1

Frontiers of Environmental Science & Engineering 2023, Volume 18, Issue 4, doi: 10.1007/s11783-024-1808-3

Abstract:

● The first study of electrochemically active magnetotactic bacteria.

Keywords： Magnetotactic bacteria Magnetospirillum magneticumi> Magnetospirillum gryphiswaldensei>

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A novel variant in the gene in a large Chinese family with a unique phenotype of Clouston syndrome

Frontiers of Medicine 2023, Volume 17, Issue 2, Pages 330-338 doi: 10.1007/s11684-022-0933-2

Abstract: To date, four mutations in the GJB6i> gene, G11R, V37E, A88V, and D50N, have been confirmed to causeIn previous studies, the focus has been mainly on gene sequencing, and there has been a lack of research

Keywords： Clouston syndrome whole exome sequencing GJB6i> gene novel variant unique phenotype

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Superior performance in visible-light-driven hydrogen evolution reaction of three-dimensionally ordered macroporous SrTiO decorated with ZnCdS

Frontiers of Chemical Science and Engineering 2021, Volume 15, Issue 6, Pages 1561-1571 doi: 10.1007/s11705-021-2089-z

Abstract: In this study, we demonstrate the fabrication of three-dimensionally ordered macroporous SrTiO₃ decorated with Zn_xi>Cd₁₋_xi>S nanoparticles for hydrogenobtained composites could afford very high hydrogen production efficiencies up to 19.67 mmol·g^{−10.5Cd_0.5S (4.67 mmol·g⁻¹·h⁻¹) and CdS (0.82 mmol·g⁻¹·h⁻¹), respectively.}

Keywords： three-dimensionally ordered macroporous SrTiO₃ Zn_xi>Cd_1–_xi>S visible light hydrogen production promotion mechanism

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Title Author Date Type Operation

Novel variants in LAMA3 and COL7A1 and recurrent variant in KRT5 underlying epidermolysis bullosa in

Journal Article

Identification of variants associated with sporadic thoracic aortic dissection: a case--control study

Journal Article

NES1i>/KLK10i> and hNISi> gene therapy enhanced iodine-131 internal radiation in PC3 proliferation

Jiajia Hu, Wenbin Shen, Qian Qu, Xiaochun Fei, Ying Miao, Xinyun Huang, Jiajun Liu, Yingli Wu, Biao Li

Journal Article

APPLE SUMO E3 LIGASE MDSIZ1 NEGATIVELY REGULATES DROUGHT TOLERANCE

Baohua CHU, Jia SUN, Huan DANG, Ziqing MA, Shuang ZHAO, Qingmei GUAN, Xuewei LI

Journal Article

RR1i> and RR2i> gene deletion affects the immunogenicity of a live attenuated pseudorabies

Shijun YAN,He YAN,Chaolin ZHANG,Tongyan WANG,Qingyuan YANG,Zhe SUN,Yan XIAO,Feifei TAN,Xiangdong LI,Kegong TIAN

Journal Article

Distinct gene expression pattern of mutations coordinated by target repression and promoter hypermethylation

Journal Article

Identification of an E3 ligase-encoding gene

Yanfei Zhang, Xinchun Zhao, Yongchun Zhou, Min Wang, Guangbiao Zhou

Journal Article

Construction of a CaHPO4-PGUS1 hybrid nanoflower through protein-inorganic self-assembly, and its applicationin glycyrrhetinic acid 3-O-mono-β-D-glucuronide preparation

Tian Jiang, Yuhui Hou, Tengjiang Zhang, Xudong Feng, Chun Li

Journal Article

Band-gap tunable (Ga_xi>In₁₋_xi>)₂O₃ layer

Fabi Zhang, Jinyu Sun, Haiou Li, Juan Zhou, Rong Wang, Tangyou Sun, Tao Fu, Gongli Xiao, Qi Li, Xingpeng Liu, Xiuyun Zhang, Daoyou Guo, Xianghu Wang, Zujun Qin,zhangfabi@outlook.com,qinzj@guet.edu.cn

Journal Article

Association of gene variants with juvenile amyotrophic lateral sclerosis

Journal Article

Gene delivery into isolated

Nan Zheng, Ziyuan Song, Yang Liu, Lichen Yin, Jianjun Cheng

Journal Article

A novel aldo-keto reductase gene,

Jinxi HUO, Bing DU, Sifan SUN, Shaozhen HE, Ning ZHAO, Qingchang LIU, Hong ZHAI

Journal Article

Electroactivity of the magnetotactic bacteria AMB-1 and MSR-1

Journal Article

A novel variant in the gene in a large Chinese family with a unique phenotype of Clouston syndrome